Arteriovenous malformations (AVMs) are tangles of abnormal blood vessels. They can form wherever arteries and veins exist, and can be found anywhere in the body. AVMs of the central nervous system (brain and spinal cord) have the most serious symptoms and complications.
Arteriovenous Malformation in the Brain
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The exact cause of AVMs is unknown.
Factors that may increase your chances of an AVM include: Family history—Some types of arteriovenous malformations are from genetic defects that can be passed on from one generation to the next.Prior head injuryPrior surgery or radiation therapy
Many times, symptoms may not be present. In those that have them, symptoms can vary from person to person. Symptoms depend on the size and location of the AVM.
An AVM in the brain may cause: HeadachesSeizuresLoss of movement on one side of the bodyMuscle weaknessUnable to perform movements, but not due to loss of movementLoss of coordination, especially when walkingSudden, severe back painDifficulty speaking or understanding languageVisual problemsMemory lossDifficulty thinking or mental confusion
Serious complications of bleeding can lead to: Hemorrhagic strokeSubarachnoid hemorrhagePressure inside the skull—encephalitisBrain damage
You will be asked about your symptoms and medical history. A physical exam will be done. Some AVMs are found during an imaging test for another reason.
Imaging tests are done to evaluate the brain and spinal cord. Contrast material may be used to make structures easier to see. These may include: Cerebral
angiographyMR angiographyCT angiographyCT scanMRI scan
You may be referred to a specialist who has experience in treating AVMs. Treatment may in a specialized intensive care unit. The goal of treatment is to destroy or remove the AVM, and prevent further bleeding, which can lead to serious complications.
Treatment options vary depending on whether or not the AVM ruptured. A combination of therapies may be used.
Medications can also be used to treat complications associated with an unruptured AVM. These may include: Pain relieversAnticonvulsants to treat seizures Medications to reduce pressure inside the skullMedications to control high blood pressureMedications to control diabetesCareful use of blood thinners
If the AVM ruptured, surgery may be delayed for 2-6 weeks. The type of surgery will depend on the size and location of the AVM. Surgical procedures include: Microsurgery—An operating microscope is used to surgically remove the AVM through an opening in the skull. Embolization—A catheter is guided through the artery until it reaches the AVM. A substance is injected through the catheter to plug the fistula. This procedure reduces the blood flow to the AVM. Embolization is more common with AVMs that are deeper in the brain.Radiosurgery—A beam of radiation is focused on the AVM. The radiation destroys the walls of the blood vessels that lead to an AVM. Stereotactic radiosurgery (SRS) delivers radiation in a very precise location. It allows for delivery of a higher dose of radiation.
There are no current guidelines to prevent AVMs because the cause is unknown. If AVMs run in your family, talk to your doctor about your options.
Arteriovenous malformation information page. National Institute of Neurological Disorders and Stroke website. Available at:
http://www.ninds.nih.gov/disorders/avms/avms.htm. Updated May 26, 2016. Accessed December 12, 2016.
Geibprasert S, Pongpech S, Jiarakongmun P, Shroff MM, Armstrong DC, Krings T. Radiologic assessment of brain arteriovenous malformations: what clinicians need to know.
Ogilvy CS, Stieg PE, Awad I, et al. AHA Scientific Statement: Recommendations for the management of intracranial arteriovenous malformations: a statement for healthcare professionals from a special writing group of the Stroke Council, American Stroke Association.
Spinal cord arteriovenous malformations (AVMs). Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/neurologic-disorders/spinal-cord-disorders/spinal-cord-arteriovenous-malformations-avms. Updated October, 2016. Accessed December 12, 2016.
What is an arteriovenous malformation (AVM)? American Stroke Association website. Available at: http://www.strokeassociation.org/STROKEORG/AboutStroke/TypesofStroke/HemorrhagicBleeds/What-Is-an-Arteriovenous-Malformation-AVM_UCM_310099_Article.jsp#.WE7w2k2QwdU. Updated November 21, 2016. Accessed December 12, 2016.
Last reviewed June 2016 by Michael J. Fucci, DO, FACC
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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