THURSDAY, Oct. 3 (HealthDay News) -- Researchers report they
have found a more palatable way to deliver a decidedly unappealing
treatment that can cure a potentially deadly intestinal
Until now, the transplantation of healthy fecal bacteria into a
patient's gut to tackle
Clostridium difficileinfections could only be done one of
three ways: with an enema; a colonoscopy (placing a tube in the
colon); or via a tube snaked through the nose and down the throat.
But Canadian scientists have created capsules containing a
concentrate of fecal bacteria that can simply be swallowed by the
"It's much more palatable for patients," said Dr. Tom Moore, a
clinical professor of medicine at the University of Kansas, who was
not involved with the study. "It takes a lot of the 'ick factor'
Even better, the capsules stopped recurring bouts of
C. difficile, the Canadian researchers discovered. They plan
to report their findings Thursday at IDWeek 2013, the infectious
diseases society conference in San Francisco.
A reliable cure for
C. difficileis much needed. The U.S. Centers for Disease
Control and Prevention recently named the harmful bacteria one of
the three most urgent health threats caused by the rise of
C. difficileitself is not antibiotic-resistant, but it gains
a foothold in the gut when healthy intestinal flora are decimated
by strong antibiotics used to overcome the resistance of other
C. difficilecauses severe diarrhea in already weakened
patients. About 250,000 people in the United States suffer from
C. difficileinfections every year and about 14,000 die,
according to the CDC.
Doctors crafted the capsules by running healthy stool through a
sieve, and then using a centrifuge to separate out the fecal
bacteria and "discard everything but the bug," said study author
Dr. Thomas Louie, a professor of medicine at the University of
Calgary, in Alberta.
The remaining fecal bacteria resembles off-white river clay,
Louie said. It is scooped into a gelatin capsule, which is then
placed inside two other layers of gelatin capsule to ensure that
the bacteria will make it through the stomach to reach the lower
intestine and the colon.
The researchers provided the pills to 27 patients with
C. difficileand reported a 100 percent success rate. None of
the patients had a recurrence of the infection, even though all of
them previously had had repeat bouts with the germ. Patients
ingested between 24 and 34 capsules containing fecal bacteria,
often donated by family members.
Moore compared fighting
C. difficilewith fecal bacteria to restoring a lawn that has
become infested with weeds.
C. difficilecan be destroyed using antibiotics, much like
using herbicides to get rid of the weeds, but that does nothing to
restore the "lawn" within the gut to proper balance.
Alternatively, one can choose to reseed the lawn with fresh
grass seed and hope the new grass crowds out the weeds. In the case
C. difficile, probiotics can sometimes boost healthy
intestinal flora that crowd out the bad bug, Moore explained.
Fecal transplantation is more akin to planting fresh sod across
the entire lawn, he suggested.
"This study confirms what has been suspected for quite some
time, that fecal transplants are the most effective and most
efficient way to restore gut health in patients with recurrent
C. diff," Moore said.
Further, he believes using capsules will make the process much
easier for people.
Moore said he sees no reason why doctors can't begin using
handmade fecal bacteria capsules to treat
C. difficile, particularly since the U.S. Food and Drug
Administration has lifted a moratorium it had placed on the
"I think the gelatin capsule idea could be enacted without
regulatory difficulty," Moore said. "The trick is to get the
gelatin capsules and actually stuff them with the stool. Certainly,
there's no glamor in it."
The data and conclusions of research presented at medical
meetings should be viewed as preliminary until published in a
For more information on
C. difficile, visit the
U.S. Centers for Disease Control and