Primaxin®(as a combination product containing Cilastatin, Imipenem)
Your doctor has ordered imipenem and cilastatin, an antibiotic, to help treat your infection. The drug will be either injected into a large muscle (such as your buttock or thigh) or added to an intravenous fluid that will drip through a needle or catheter placed in your vein for about 30 minutes, two to four times a day.
The combination of imipenem and cilastatin eliminates bacteria that cause many kinds of infections, including pneumonia and gynecological, skin, stomach, blood, bone, joint, urinary tract, and heart valve infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Your health care provider (doctor, nurse, or pharmacist) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how your infection and symptoms respond to the medication.
Before administering imipenem and cilastatin, tell your doctor and pharmacist if you are allergic to imipenem, penicillin, cephalosporins [e.g., cefaclor (Ceclor), cefadroxil (Duricef), and cephalexin (Keflex)], or any other drugs.tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antibiotics and vitamins.tell your doctor if you have or have ever had seizures; a brain injury; kidney, liver, or gastrointestinal disease (especially colitis); or asthma.tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking imipenem and cilastatin, call your doctor.if you have diabetes and regularly check your urine for sugar, use Clinistix or TesTape. Do not use Clinitest tablets because this drug may cause false positive results.
Before you administer imipenem and cilastatin, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.
It is important that you use your medication exactly as directed. Do not stop your therapy on your own for any reason because your infection could worsen and result in hospitalization. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.
Imipenem and cilastatin may cause side effects. If you are administering imipenem and cilastatin into a muscle, it probably will be mixed with lidocaine (Xylocaine) to reduce pain at the injection site. Tell your health care provider if any of these symptoms are severe or do not go away: upset stomachvomitingstomach pain
If you experience any of the following symptoms, call your health care provider immediately: diarrhearashitchingfeverchillsfacial swellingwheezingdifficulty breathingunusual bleeding or bruisingdecreased urinationdizzinessconfusionseizuressore mouth or throat
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( Web Site) or by phone (1-800-332-1088).
Your health care provider probably will give you a several-day supply of imipenem and cilastatin at a time. If you are receiving imipenem and cilastatin intravenously (in your vein), you probably will be told to store it in the refrigerator.Take your next dose from the refrigerator 1 hour before using it; place it in a clean, dry area to allow it to warm to room temperature.
If you are receiving imipenem and cilastatin intramuscularly (in your muscle), your health care provider will tell you how to store it properly.
Store your medication only as directed. Make sure you understand what you need to store your medication properly.
Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
If you are receiving imipenem and cilastatin in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin). If you experience any of these effects near your intravenous catheter, tell your health care provider as soon as possible: tendernesswarmthirritationdrainagerednessswellingpain
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Last Reviewed: August 1, 2010.