Gastroparesis is a disorder that affects the digestive system. During normal digestion, the stomach breaks down food and then contracts to push food down to the small intestine. With gastroparesis, there is delayed emptying of the stomach. Food either moves slowly through the digestive tract or does not move at all. This can pose problems since the food can harden causing blockage, nausea, and vomiting. Bacteria can also start to grow. Gastroparesis is a potentially serious condition. It requires care from your doctor.
The Stomach and Intestines
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Movement of food in the digestive system is controlled by the vagus nerve. Gastroparesis occurs when this nerve is damaged and the muscles of the stomach do not work properly.
The main risk factor is
diabetes. Diabetes can damage the vagus nerve, which may lead to gastroparesis. High blood glucose can also damage blood vessels that carry nutrients and oxygen to the vagus nerve, preventing it from working properly. Other risk factors include:
Gastroesophageal reflux disease
Surgery that involves the stomach or vagus nerveTaking certain medications, such as anticholinergics or opioidsInfection from a virusDiseases affecting the nerves, muscles, or hormonesDiseases affecting metabolism (body’s ability to make and use energy)Chronic diseaseAnorexia
Gastroparesis may cause: Feeling full early during a mealNo appetiteNausea and vomitingBloatingPain in your abdomen or esophagus (the muscular tube that carries food from your mouth to your stomach)HeartburnWeight loss
The following may worsen symptoms: High-fiber foods, like raw vegetables and fruitsFatty foodsCarbonated drinks
Your doctor will ask about your symptoms and medical history. A physical exam will also be done. The doctor may do: Blood tests
Tests to measure:
Stomach volume before and after a mealThe rate at which the stomach emptiesThe ability of the muscles in the stomach and small intestine to contract and relax
Imaging tests can assess the stomach and surrounding structures:
or CT scanGastric emptying study— may also be done by MRI scan
Upper GI endoscopy—a thin, lighted tube inserted down the throat to examine the esophagus, stomach, and small intestine
SmartPill—a pill-sized device that is swallowed to capture information on the digestive system
Talk with your doctor about the best treatment plan for you. Treatment options include:
Managing what you eat can help control gastroparesis. You may work with your doctor or a registered dietitian to create a meal plan that is right for you. This may include: Eating small meals several times throughout the dayFollowing a liquid diet
and high-fiber foods
In severe cases, nutrients can be delivered to the body by going directly into the intestines or bloodstream. These methods bypass the stomach. Access to the intestines can be done with a tube that goes down the throat or through an opening in the abdominal wall. A tube in the vein can access the bloodstream.
You may be given medications to treat the symptoms and help the stomach with emptying. These medications work by stimulating the stomach muscles to contract. Examples include: MetoclopramideErythromycin
Other medications may be prescribed to reduce nausea.
To help reduce your chance of gastroparesis:
If you have diabetes, follow your treatment plan.
Avoid medications that delay gastric emptying. These include opioids, calcium channel blockers, and some antidepressants. Keep a list of all the medications you are taking and share this list with your doctor. Make sure you talk to your doctor before stopping any medications.
Gastroparesis. American College of Gastroenterology website. Available at:
http://patients.gi.org/topics/gastroparesis. Accessed April 4, 2011.
Gastroparesis. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at:
http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/gastroparesis/Pages/facts.aspx. Updated July 2007. Accessed April 4, 2011.
Shakil A, Church RJ, Rao SS. Gastrointestinal complications of diabetes.
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Soykan I, Sivri B, Sarosiek I, Kiernan B, McCallum RW. Demography, clinical characteristics, psychological and abuse profiles, treatment, and long-term follow-up of patients with gastroparesis.
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Last reviewed March 2016 by Daus Mahnke, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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