Mild cognitive impairment–amnestic type (MCI-AT) is mild, repeated memory loss. It lies between the normal memory loss of aging and the more serious conditions of
Alzheimer's disease. MCI-AT only involves problems with memory.
People with MCI-AT who are over age 65 have a higher chance of developing dementia and Alzheimer's. However, many people with MCI-AT never develop these disorders. Some even return to normal.
Areas of the Brain
Copyright © Nucleus Medical Media, Inc.
The causes are not clear. However, genetic factors may be a cause.
Factors that may increase your chance of developing MCI-AT include: Family history of MCI-AT, dementia, or Alzheimer's
Medical conditions, such as
high blood pressure, heart disease,
stroke, head injury,
anxiety, or infections
Lack of physical activityOvermedicationSubstance abuse
Research also suggests that these may be risk factors for MCI-AT: SmokingLack of social contactLow educational levelExcessive response to stressPoor nutrition and lack of vitaminsExposure to toxins
The main symptom is frequent, ongoing memory loss beyond what is normally expected for your age. That means having more than small lapses of memory. If you have MCI-AT, you may: Remember much less of what you have just read or seen than people who have only the normal memory changes of agingTake longer to recall information
The doctor will ask about your symptoms and medical history. A physical exam will be done. The doctor may also talk with family members and caregivers.
Tests may include: Memory and cognitive skill testsBlood testsLumbar puncture—to test the protective fluid around the brain and spinal cord for possible causes
Imaging tests take pictures of internal bodily structures. This can be done with: MRI scanPET scanSPECT scan
Treatment is focused on:
Preventing, or at least slowing down, further loss of memory and other cognitive abilities using
Cognitive interventionOccupational therapyPreventing dementia and Alzheimer's disease
Researchers are currently studying the effects that several medications may have on slowing cognitive decline. These include: Cholinesterase inhibitorsMood stabilizers
To help reduce your chance of developing MCI-AT, take these steps: Manage medical conditions, especially high blood pressureManage
psychiatric conditions, such as depressionStay mentally active by doing things like memory exercises, crossword puzzles, reading, and taking classesGet regular exerciseParticipate in social activitiesReduce stress
Birks J, Flicker L. Donepezil for mild cognitive impairment.
Cochrane Database Syst Rev. 2006;3:CD006104.
DeKosky ST, Williamson JD, Fitzpatrick AL, et al. Ginko biloba for prevention of dementia: A randomized controlled trial.
Feldman HH, Jacova C. Mild cognitive impairment.
Am J Geriatr Psychiatry. 2005;13(8):645-655.
Gauthier S, Reisberg B, Zaudig M, et al. Mild cognitive impairment.
Institute for the Study of Aging and International Longevity Center–USA (March 2001).
Achieving and Maintaining Cognitive Vitality With Aging: A Workshop Report. New York, NY.
Mild cognitive impairment. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated August 23, 2013. Accessed September 5, 2013.
National Institute on Aging.
2011-2012 Alzheimer's Disease Progress Report.
Accessed September 5, 2013.
Petersen RC. Mild cognitive impairment: Current research and clinical implications.
Semin Neurol. 2007;27(1):22-31.
Petersen RC, Roberts RO, Knopmann DS, et al. Mild cognitive impairment: Ten years later.
Arch Neurol. 2009;66(12):1447-1455.
Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome.
Archives of Neurology. 1999;56(3):303-308.
Last reviewed August 2015 by Rimas Lukas, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved.