A risk factor is something that increases your chances of developing cancer.
It is possible to develop pancreatic cancer with or without the risk factors listed below. However, the more risk factors you have, the greater your likelihood of developing
pancreatic cancer. If you have a number of risk factors, ask your doctor what you can do to reduce your risk.
In general, pancreatic cancer is more common in people over the age of 50 years. The average age at diagnosis is 65 years of age. Risk is nearly twice as high in men as in women. Other factors that may increase your chance of pancreatic cancer include:
and using smokeless tobacco is a clear risk factor for the development of pancreatic cancer. Smoking increases risk 3-4 times more than a nonsmoker.
People with current or a history of the following may have a higher risk of pancreatic cancer: Alcohol use disorderDiabetes may increase risk 2-3 times that of someone without diabetesHistory of inflammation of the pancreas—chronic pancreatitisObesityAutoimmune disorder that leads to vitamin B12 deficiency—pernicious anemiaPrevious gastric resection
Some studies suggest that occupational exposure to certain chemicals may increase your risk of developing pancreatic cancer. Chemicals that seem to be particularly associated with pancreatic cancer include those used in the petroleum and dry-cleaning industries, pesticides, and dyes.
A diet that is low in fiber and high in fat may increase your risk of developing pancreatic cancer.
Some families seem to have a genetic predisposition to develop certain types of cancer, including pancreatic cancer. If your mother, father, brother, or sister has had pancreatic cancer, you are 3 times as likely to develop the disease yourself. The presence of
within your family also increases your risk of developing pancreatic cancer.
About 10% of pancreatic cancers are due to hereditary factors. The following hereditary conditions increase the risk of pancreatic cancer:
Cystic fibrosisFamilial multiple mole melanoma syndromePeutz-Jeghers syndromeNon-polyposis colorectal cancer syndromeFamilial breast cancer syndrome
African Americans have a greater risk—30%-40%—of developing pancreatic cancer than Caucasians. People of Hispanic origin or Asian Americans are less commonly affected.
Cruz MD, Young AP, Ruffin MT. Diagnosis and management of pancreatic cancer.
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Pancreatic cancer. American Cancer Society website. Available at:
http://www.cancer.org/acs/groups/cid/documents/webcontent/003131-pdf.pdf. Accessed September 8, 2016.
Pancreatic cancer. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/gastrointestinal-disorders/tumors-of-the-gi-tract/pancreatic-cancer. Updated July 2014. Accessed September 8, 2016.
Last reviewed September 2016 by Mohei Abouzied, MD, FACP
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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