Depression is a condition characterized by feelings of profound sadness or a lack of interest in formerly enjoyable activities. There are a variety of factors that can lead to depression, including some common medications. However, the relationship may be more complicated than simple medication.
Depression caused by medications is diagnosed differently than for people who do not take medications. Medication-induced depression is a significant and persistent change in mood that occurs during use of certain medications, or within 1 month of intoxication with or withdrawal of
medication therapy. Symptoms may include:
Persistent feelings of sadness,
anxiety, or emptiness
Restlessness or irritability (may be only symptoms present in children or adolescents)Feeling guilty, worthless, or helplessLoss of interest in hobbies and activitiesFeeling tiredTrouble concentrating, remembering, making decisionsTrouble sleeping, waking up too early, or oversleepingChanges in appetite or weightThoughts of death or suicide, with or without suicide attemptsPhysical symptoms without a standard diagnosis and not responding well to medical treatment
If you have any of these symptoms, consider checking your medicine cabinet. See if some of the medications you take could be at the root of your depression problems.
Some evidence supports the association of depression with many medications, including: InterferonTriptans for migraine headachesOral contraceptives or other hormonal treatmentsCorticosteroidsMedications to treat other psychiatric conditionsAnti-seizure medicationsOral acne medications (isotretinoin)Medications used to quit smokingCertain antiviral medicationsCardiovascular medications
Although many medications have been identified, evidence to support medication-induced depression is limited and conflicting. Because depression is so complex, other factors may affect your mood as well.
It is important to remember, most people who take these medications will not become depressed AND not all cases of depression in people taking these medications will be a result of the medication.
The medical conditions that require some of these medications can themselves lead to depression. In addition, people with depression are more prone to certain medical conditions that require treatment. So, it is not always clear whether certain medications cause depression, or if people with depression more apt to need certain medications. Here are some other things that may also contribute to depression: Chronic illness, like cancer or heart diseaseUnknown or unrecognized mental illnessSocial factors, like unemployment or disabilityPast history with depression
The elderly may also be at higher risk for depression. It is common for elderly to have multiple medication prescriptions. It is possible that drugs which may not cause depression when taken alone, may do so when given in combination with other medications.
Although other risk factors can muddy the waters, take some time to think about the onset of symptoms and the timing of the medication. Work with your doctor to determine which factors may be contributing to your symptoms. Your doctor may suggest changing or altering the medications you take. Do not stop taking prescription medication without talking to your doctor.
Whatever the cause, depression is treatable. Treatment will make you feel better, help you be more productive, and help you control whatever other health problems you might have.
Botts S, Ryan M. Depression. Association Schools of Public Health website. http://www.ashp.org/DocLibrary/Policy/Suicidality/DID-Chapter18.aspx PDF. Accessed July 19, 2016.
Drug safety information. US Food and Drug Administration website. Accessed at http://www.fda.gov/Drugs/ResourcesForYou/HealthProfessionals/DrugSafetyInformation/default.htm. Updated April 6, 2016. Accessed July 19, 2016.
Kotlyar M, Dysken M, Adson DE. Update on drug-induced depression in the elderly.
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Patten SB, Barbui C. Drug-induced depression: a systematic review to inform clinical practice.
Last reviewed July 2016 by Michael Woods, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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