Diabetic neuropathy is a type of nerve damage associated with diabetes. It results in damage to the nerves in a person’s feet, legs, and eyes, and to the nerves that control bodily functions, such as digestion, blood pressure, and heart rate.
Nerves of the Foot
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Diabetic neuropathy is likely caused by a combination of factors, including:
Metabolic syndrome—A condition marked by elevated blood pressure, cholesterol, blood glucose, and body weight. Excess weight centered around the midsection is of particular concern. Damage to blood vesselsAutoimmune factorsGenetics
Symptoms of diabetic neuropathy may include:
Numbness , tingling, or pain in the extremitiesWeakness in arms and or legsIndigestionNausea or vomitingDiarrhea
or vaginal dryness
Weakness of facial muscles resulting in drooping eyelid, drooping mouth, facial droop, difficulty swallowingMuscle crampsA prolonged feeling of fullness after eating, and/or abdominal painDecreased ability to sweat normally
If you have diabetic neuropathy, you are at increased risk for developing other types of neuropathies, such as
carpal tunnel syndrome
Diabetic neuropathy can lead to serious complications, including
ulcers, infection, and limb loss.
You will be asked about your symptoms and medical history. A physical exam will be done. A foot exam will also be done.
Your nerve function may be tested. This can be done with: Nerve conduction studiesElectromyographyQuantitative sensory testing—the use of stimuli to check for neuropathyQuantitative sudomotor axon reflex test—a test to evaluate the nerve supply of sweat glands
Images may be taken of your bodily structures. This can be done with an ultrasound.
Your nerves may need to be tested. This can be done with a biopsy.
Talk with your doctor about the best treatment plan for you. Treatment options include:
It is important to regularly monitor blood glucose levels. You can bring them within normal range with meal planning, exercise, and/or medications.
If you have diabetic neuropathy, you will need to take special care of your feet. The nerves in the feet are the ones most often affected by neuropathy. This care will involve regular visits to a foot doctor and careful cleaning, inspection, moisturizing, and grooming of your feet. In addition, always wear well-fitting shoes and thick, soft, seamless socks to help protect your feet from injuries.
If you have painful diabetic neuropathy, nerve decompression surgery may be done to reduce pain. Talk to your doctor about whether this option is right for you.
Other treatments will depend on your symptoms. Medications can be used to relieve pain, burning, tingling, or numbness. Often, the medications used to treat these symptoms are the same ones used to treat
Another option to treat pain is called transcutaneous electrical nerve stimulation (TENS). With TENS, a machine sends painless electrical signals through the skin to the nerves. Your doctor may offer this treatment.
The best way to prevent diabetic neuropathy is to regularly monitor and manage your blood glucose levels. Your doctor can instruct you about how often to check your levels and what the numbers mean.
Diabetic neuropathies: the nerve damage of diabetes. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at:
Updated November 26, 2013. Accessed September 8, 2015.
Diabetic peripheral neuropathy. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated July 13, 2015. Accessed September 8, 2015.
England JD, Gronseth GS, Franklin G, et al. Practice Parameter: Evaluation of distal symmetric polyneuropathy: role of laboratory and genetic testing (an evidence-based review). Neurology. 2009;72(2):185-192.
Ogawa K, Sasaki H, Yamasaki H, et al. Peripheral nerve functions may deteriorate parallel to the progression of microangiopathy in diabetic patients.
Nutr Metab Cardiovasc Dis.
Types of peripheral neuropathy: pre-diabetic/diabetic
University of Chicago Center for Peripheral Neuropathy website.
Available at: http://peripheralneuropathycenter.uchicago.edu/learnaboutpn/typesofpn/diabetes/diabetes.shtml. Accessed September 19, 2014.
Vinik AI, Mehrabyan A. Diabetic neuropathies.
Med Clin North Am.
2/4/2010 DynaMed's Systematic Literature Surveillance
http://www.ebscohost.com/dynamed: Dubinsky RM, Miyasaki J. Assessment: efficacy of transcutaneous electric nerve stimulation in the treatment of pain in neurologic disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
6/16/2015 DynaMed's Systematic Literature Surveillance
http://www.ebscohost.com/dynamed: Macaré van Maurik JF, Oomen RT, et al. The effect of lower extremity nerve decompression on health-related quality of life and perception of pain in patients with painful diabetic polyneuropathy: a prospectrive randomized trial. Diabet Med. 2015;32(6):803-809.
Last reviewed September 2015 by Kim Carmichael, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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