Gilbert syndrome is a genetic liver disorder. It causes levels of bilirubin to rise above normal levels. Bilirubin is a yellow chemical by-product of hemoglobin. Hemoglobin is the red pigment in blood cells that is usually excreted by the liver as bile.
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Gilbert syndrome is usually caused by an inherited genetic abnormality. Symptoms occur when there is an interference with the liver enzyme that is important in the elimination of bilirubin. This causes the levels of bilirubin to increase in the blood, which may produce symptoms such as
Gilbert syndrome is more common in males, and in those with a family history.
Often, there are no symptoms of Gilbert syndrome. However, people who do have symptoms may experience: Yellowing of the skin known as jaundiceJaundice of the whites of the eyesAbdominal painLoss of appetiteFatigue and weaknessDarkening of the urine
Your doctor will ask about your symptoms and medical history. A physical exam will be done. Tests may include: Blood testsReticulocyte countTotal and direct bilirubinLiver function tests
Blood tests are also done to rule out more serious liver diseases, such as
hepatitis. Sometimes, a
may also need to be done.
No treatment is necessary for Gilbert syndrome. Usually, symptoms come and go.
There is no way to prevent Gilbert syndrome. However, you may prevent symptoms by avoiding the following: Skipping meals or fastingDehydrationVigorous exerciseRepeated bouts of vomitingStress or trauma
Gilbert syndrome. American Liver Foundation
website. Available at:
Updated October 4, 2011. Accessed May 30, 2013.
Gilbert syndrome. Genetics Home Reference website. Available at:
http://ghr.nlm.nih.gov/condition/gilbert-syndrome. Updated February 2012. Accessed May 30, 2013.
Last reviewed February 2015 by Michael Woods, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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