Squamous cell carcinoma is a form of skin cancer. It is the second most common form of skin cancer.
The cancer develops in the uppermost layer of skin cells. Squamous cell carcinoma usually grows slowly. It is rarely fatal if treated early. However, the cancer can be lethal if it spreads beyond the skin.
Copyright © Nucleus Medical Media, Inc.
Cancer occurs when cells in the body divide without control or order. Eventually these uncontrolled cells form a growth or tumor. The growths invade and take over nearby tissue. It is not clear exactly what causes these problems in the cells but it is probably a combination of genetics and the environment.
Areas of skin that are damaged have a higher risk of cancer. Skin that is regularly exposed to the sun is more likely to develop skin cancer. Squamous cell carcinoma may also develop in skin that has scars, burns, or exposure to chemicals or radiation.
Factors that may increase your chance of developing squamous cell carcinoma include: History of radiation or ultraviolet light treatment
, freckling, or long periods of sun exposure
A personal history of skin cancerA family history of skin cancerBlonde or red hairBlue or green eyesFair skin that rarely tansTreatments or medications that suppress the immune systemFrequent use of tanning bedsExposure to cancer causing chemical such as arsenic, tar, or some insecticidesSmokingPast infection with human papillomavirus (HPV)
Symptoms include: A raised red patch that is scaly or roughA raised patch of skin that may appear to have horn-like rough edgesIn color, the patch may be reddish, pink, flesh-colored, or reddish-brownA long-standing sore that will not heal with simple at-home treatment
The doctor will ask about your symptoms and medical history. A physical exam will be done.
The skin growth will be examined. A sample of the growth will be taken and examined for cancer cells. This will help determine the stage and type of the cancer.
The information will be used to guide treatment and make a prognosis.
Talk with your doctor about the best treatment plan for you. Options include: Mohs micrographic surgery—microscopic surgery that offers the best cure rate for squamous cell carcinomaRemoving the growth with simple surgeryPlastic surgery to repair any cosmetic problems that occur after treatment
For people who are not able to have surgery, other treatment options include: Freezing the growth off with liquid nitrogenLaser treatment
Radiation therapyPhotodynamic therapy—the cells absorb an acid that causes them to die when exposed to lightTopical creams, especially fluorouracil or imiquimod
To help reduce the chance of squamous cell carcinoma: Avoid spending too much time in the sun.Avoid exposing your skin to the sun between 10:00 AM and 2:00 PM standard time, or 11:00 AM to 3:00 PM daylight saving time.Protect your skin from the sun with clothing. Wear a shirt, sunglasses, and a hat with a broad brim.Use broad-spectrum (UVA and UVB) sunscreens with a sun protection factor (SPF) of 30 or more on skin that will be exposed to the sun.Use a protective lip balm. Wear sunglasses with 99% to 100% UV absorption to protect your eyes.Do not use sun lamps or tanning booths.Get regular full-body skin exams by a dermatologist. The doctor will check for moles, freckles, and other growths.
Alberta Provincial Cutaneous Tumour Team. Prevention of skin cancer. Edmonton (Alberta): CancerControl Alberta; 2013 Feb. 27 p. (Clinical practice guideline; no. CU-014). Available at: http://www.guideline.gov/content.aspx?id=48130#Section420. Accessed February 25, 2015.
Jerant A, Johnson J, Sheridan CD, Caffrey TJ. Early detection and treatment of skin cancer.
Am Fam Physician. 2000;62(2):357-368.
Saraiya M, Glanz K, Briss P, et al. Preventing skin cancer.
Squamous cell carcinoma (SCC). EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated January 16, 2015. Accessed February 25, 2015.
Squamous cell carcinoma. American Academy of Dermatology website. Available at:
https://www.aad.org/public/diseases/skin-cancer/squamous-cell-carcinoma. Accessed February 25, 2015.
Sunscreen FAQs. American Academy of Dermatology website. Available at: https://www.aad.org/media/stats/prevention-and-care/sunscreen-faqs. Accessed February 25, 2015.
Last reviewed March 2016 by James Cornell, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved.