The information provided here is meant to give you a general idea about each of the medicines listed below. Only the most general side effects are included, so ask your doctor if you need to take any special precautions. Use each of these medicines as recommended by your doctor, or according to the instructions provided. If you have further questions about usage or side effects, contact your doctor.
The type of treatment you will have will depend on the stage of the cancer, the size of the tumor, your age, and overall condition. The main prescription drug therapies used to treat prostate cancer are hormonal therapies.
Prostate cells need male hormones, called androgens, to grow and work properly. The aim of hormonal therapy is to reduce the amount of male hormones in your body so that prostate cells are not stimulated to grow. The most effective hormonal therapy is to undergo surgery to remove the testes (called orchiectomy). This is effective surgery, but it is irreversible. Often hormonal therapies are combined to achieve greater effects.
Different types of hormonal therapies include:
Common names include: Leuprolide
These medicines decrease the production of the male hormone, testosterone, from your testicles. These medicines are given by injection into a muscle every few months.
Possible side effects include: ImpotenceHot flashesLoss of sexual desireOsteoporosisFatigueIncreased risk of heart disease and diabetes
Common names include: Flutamide
Anti-androgens prevent your body from using androgens.
Possible side effects include: Nausea and vomitingDiarrheaBreast growth or tendernessChange in sexual ability or desire
Ketoconazole blocks the production of androgens. It is considered a second-line hormonal treatment. It may be used when other medicines are not working.
Possible side effects include: Nausea and vomitingLiver problemsItchy skin
Common name: abiraterone (Zytiga)
Abiraterone works by blocking an enzyme that is needed to make testosterone. The drug affects the ability of the testes and body tissue from making this male hormone.
Possible side effects include: FatigueFluid build-up in the legsJoint and muscle painHigh blood pressureBladder infection
Common name: enzalutamide (Xtandi)
This medicine has been approved by the Food and Drug Administration (FDA) for men that have late-stage prostate cancer that has not responded to other treatments.
Enzalutamide, a type of anti-antigen, prevents your body from using androgens.
Possible side effects include: WeaknessBack painDiarrheaJoint pain
If you are taking medicines, follow these general guidelines: Take your medicine as directed. Do not change the amount or the schedule.Do not stop taking them without talking to your doctor.Do not share them.Know what the results and side effects. Report them to your doctor.Some drugs can be dangerous when mixed. Talk to a doctor or pharmacist if you are taking more than one drug. This includes over-the-counter medicine and herb or dietary supplements.Plan ahead for refills so you don’t run out.
Detailed guide: prostate cancer.
American Cancer Society
website. Available at:
Accessed October 9, 2008.
2/12/2010 DynaMed's Systematic Literature Surveillance
DynaMed's Systematic Literature Surveillance
: Smith DP, King MT, Egger S, et al. Quality of life three years after diagnosis of localised prostate cancer: population based cohort study.
Last reviewed September 2013 by Mohei Abouzied, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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