Scleroderma involves a wide variety of symptoms. In most cases, people first have symptoms that are associated with
Raynaud's phenomenon causes: Changes in skin color of the fingertips, toes, and nose in response to cold or emotional stressSkin usually turns very white when first exposed to cold, then blue, then very redMay be accompanied by pain, tingling, numbness
Scleroderma may cause: Sores or ulcers on the fingersChanges in the skin as areas of affected skin lose hair and become stiff, hard, thick, and shinyTight skin over face that makes it hard to change expressionSkin creases diminish or disappearWhitish bumps of calcium deposits develop under the skin, known as calcinosis
Tiny purplish-red blood vessels appear under the skin—telangiectasias
ArthritisMuscle pain and weakness
Dry eyes and mouth—Sjögren’s syndrome
Scleroderma may cause digestive problems, such as: Heartburn
Difficulty swallowingConstipationDiarrheaWeight loss
Scleroderma may cause lung, heart, and kidney problems, such as: Shortness of breath
Abnormal heart rhythms—arrhythmias
Scleroderma. National Institute of Arthritis and Musculoskeletal and Skin Diseases website. Available at:
http://www.niams.nih.gov/Health_Info/Scleroderma/default.asp. Updated August 2012. Accessed August 8, 2013.
Systemic sclerosis. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated August 5, 2013. Accessed August 8, 2013.
What is scleroderma? Scleroderma Foundation website. Available at:
http://www.scleroderma.org/site/PageServer?pagename=patients_whatis#.V2G4ck2FPIU. Accessed August 8, 2013.
Last reviewed June 2016 by Michael Woods, MD
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