Amniotic fluid surrounds the baby during pregnancy. Amniocentesis is the removal of a small amount of this fluid for testing.
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Amniocentesis is most often done to see if there is an abnormality in your baby's genes (DNA). It can also be done to see if your baby is developing correctly. Later in pregnancy, it can be done to determine the maturity of your baby's lungs.
Factors that indicate that you may need this procedure include: Age: over 35 years at the time of deliveryFamily history of chromosome abnormalityFamily history of inherited disorder
Family history of neural tube defect—problems in spine and brain growth, such as
Abnormal results from early screening tests for chromosomal abnormalities
Depending on your risk factors, cells in the amniotic fluid are tested for:
Chromosome abnormalities. The results are usually ready within 14 days.
Missing or extra chromosomes lead to physical birth defects and
is one example.
Inherited genetic diseases—Test results are usually ready in 1-5 weeks. Examples include:
Tay-Sachs disease—Most frequent in the Ashkenazi Jewish population
Cystic fibrosis—Most frequent in Caucasians of northern European ancestry
Sickle cell disease—Most frequent in the black race
Amniocentesis may also be done: To determine whether the baby's lungs are matureIn high-risk pregnancies that may require early deliveryThere is concern for Rh-sensitization pregnancy
Complications that may occur with an amniocentesis include: Bleeding, cramping, and leaking fluid from the vaginaInfectionMixing of blood if you and your baby have different blood typesNeed for repeat testingHarm to the fetus by the needle—RareMiscarriage—Rare
Factors that may increase your risk of complications include:
obesityPrevious abdominal surgery
Be sure to discuss these risks with your doctor before the procedure.
You may be given a local anesthesia. This numbs a small area in the abdomen where the needle will be placed.
ultrasound will be done. This will help
to choose a safe spot to insert the needle. Your abdomen will be cleaned. Next, a very thin needle will be inserted through your abdomen into your uterus. A few teaspoons of amniotic fluid will be removed.
After the needle is removed, the doctor will make sure that your baby's heartbeat is normal. In most cases, an ultrasound will be used throughout the procedure.
You may feel cramping when the needle enters your abdomen. You may also feel pressure when the fluid is withdrawn.
A test showing a healthy baby is ideal. But, you will need to be prepared if the results show otherwise. If the test shows that your baby may have a genetic disorder, you may need to make tough decisions regarding your pregnancy. If you do continue with the pregnancy, then you will need to address your child's special needs. Your doctor can help you understand the pros and cons of having this test. Your doctor will work with you on options that are best for you after you know the results.
After arriving home, contact your doctor if you have: Signs of infection, including fever and chillsNausea or vomitingPain or cramping in your lower abdomen or shoulderVaginal bleeding or a loss of fluid from the vaginaRedness, swelling, increasing pain, excessive bleeding, or discharge from the amniocentesis siteNew, unexplained symptoms
In case of an emergency, call for medical help right away.
The American College of Obstetricians and Gynecologists, Invasive Prenatal Testing for Aneuploidy, Practice Bulletin No. 88, December 2007; Reaffirmed 2009.
Chorionic villus sampling (CVS). American Pregnancy Association website. Available at:
http://www.americanpregnancy.org/prenataltesting/cvs.html. Updated April 2006. Accessed March 14, 2014.
Later childbearing. American College of Obstetricians and Gynecologists website. Available at:
http://www.acog.org/~/media/For%20Patients/faq060.pdf?dmc=1&ts=20121002T1240392696. Published December 2012.
Accessed October 2, 2012.
Screening and monitoring during pregnancy. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated March 3, 2014. Accessed March 14, 2014.
Hemolytic disease of the newborn. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated March 6, 2013 Accessed April 30, 2014.
Last reviewed March 2014 by Andrea Chisholm, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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