A brain tumor occurs when cells grow uncontrollably in the brain. Cancer occurs when cells in the body divide without control or order. If cells divide uncontrollably, they form a mass of tissue. The mass is called a growth or tumor. The term cancer usually refers to
malignant tumors. These can invade nearby tissue and spread to other parts of the body. A
does not spread. But, it can continue to grow and press structures near it, causing symptoms.
There are two main types of brain tumors:
Primary brain cancer—This begins in the brain. It can be either malignant or benign. A small benign tumor in a bad location can cause significant problems.Secondary or metastatic brain cancer—This has spread to the brain from another site in the body. All metastatic tumors are malignant.
Copyright © Nucleus Medical Media, Inc.
The cause of most primary brain cancers is unknown. Secondary brain cancer is caused by the cancer spreading to the brain from another site.
Factors that increase your chance of developing brain tumors include:
RadiationA condition that affects the immune systemFamily history of certain types of cancer
Any cancer in the body can spread to the brain. The most common tumors that may spread to the brain include:
Lung cancerBreast cancerMalignant melanomasGastrointestinal tract cancerKidney cancer
Symptoms depend on the tumor's size and location. A growing tumor will often have fluid build-up around it. This is called edema. Edema puts pressure on the brain. Symptoms may develop gradually or rapidly.
Symptoms may include:
Headache—Most headaches are not caused by brain tumors. Headaches due to brain tumors may have the following features:
Worsens over a period of weeks to monthsWorse in the morning or causes you to wake during the nightDifferent than a normal headacheWorsens with change of posture, straining, or coughingSeizuresNausea or vomiting, especially early morning vomitingWeakness in arms and/or legsLoss of sensation in arms and/or legsDifficulty walkingHearing loss or vision loss, including double visionSpeech problemsDrowsinessMemory problemsPersonality changes
You will be asked your symptoms and medical history. A physical exam will be done. You will have a neurological exam. It will test muscle strength, coordination, reflexes, response to external actions, and alertness. The doctor may also look into your eyes to check for signs of brain swelling.
Images of your bodily structures may need to be taken. This can be done with: MRI scanCT scanPET scanSingle-photon emission computed tomography (SPECT)Combination PET and CT scan (PET/CT scan)Arteriography
A sample of brain tissue may need to be removed for testing. This can be done with: BiopsyStereotaxis
There are many different types of brain tumors. The doctor will classify the type. The type of brain tumor is important to determine the treatment approach.
After cancer is found, further tests may be done if there is concern that the cancer has spread. Treatment depends on the type, size, location of the cancer, and your overall health. Treatments may leave you with physical or mental limitations.
Before beginning treatment, you may take medications, including:
Steroids to decrease swelling and fluid buildupAnticonvulsants to prevent seizures
Surgical procedures include:
Craniotomy—opening the skull to remove the tumor or as much of the tumor as possible
Shunt—implanting a long thin tube in the brain to direct fluid build up to another part of the body
Radiation therapy uses radiation
to kill cancer cells and shrink tumors. This is a common treatment for brain tumors. Radiation may be:
External radiation therapy—Radiation is directed at the tumor from a source outside the body.
If you have a metastatic brain tumor, you will receive whole brain radiation therapy (WBRT). If you have a primary brain tumor, you will receive more focused radiation therapy. WRBT may also be used in people who have cancer in other areas of the body. The treatment is used to prevent brain cancer.Internal radiation therapy—Radioactive materials are placed into the body near the cancer cells.
This is used less often.Stereotactic radiosurgery—Higher doses of radiation can be delivered to the affected areas of the brain. Nearby normal tissue can be spared. Special equipment, including MRI and CT scans, help to focus the radiation.
This is most often used in metastatic brain tumors or in benign brain tumors, such as
is the use of drugs to kill cancer cells. It may be given in many forms, including pill, injection, or through a tube called a catheter. The drugs enter the bloodstream and travel through the body killing mostly cancer cells, but also some healthy cells. It may also be delivered directly into the cerebrospinal fluid, which bathes the brain tissue. This form of chemotherapy is called intrathecal.
This is most often used when cancer has spread from elsewhere in the body to the fluid surrounding the brain and spinal cord.
Rehabilitation therapy includes:
Physical therapy to help with walking, balance, and building strengthOccupational therapy to help with mastering life skills, such as dressing, eating, and using the toiletSpeech therapy to help express thoughts and overcome swallowing difficulties
There are no guidelines for preventing brain cancer.
Brain tumor. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated June 9, 2014. Accessed September 5, 2014.
Brain tumors. American Association of Neurological Surgeons. Available at:
http://www.aans.org/Patient%20Information/Conditions%20and%20Treatments/Brain%20Tumors.aspx. Updated June 2012. Accessed September 5, 2014.
Brain tumor. National Cancer Institute website. Available at:
Accessed September 5, 2014.
12/20/2007 DynaMed's Systematic Literature Surveillance
http://www.ebscohost.com/dynamed: 2007 safety alerts for drugs, biologics, medical devices, and dietary supplements: Carbamazepine (marketed as Carbatrol, Equetro, Tegretol and generics). Medwatch. US Food and Drug Administration website. Available at:
5/28/2008 DynaMed's Systematic Literature Surveillance
Tremont-Lukats IW, Ratilal BO, Armstrong T, Gilbert MR. Antiepileptic drugs for preventing seizures in people with brain tumors.
The Cochrane Library.
2008; DOI: 10.1002/14651858.CD004424.pub2.
Last reviewed August 2014 by Mohei Abouzied, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved.