Ulcerative colitis (UC) is a type of severe, chronic
inflammatory bowel disease
(IBD), which causes:
Inflammation in the lining of the colon and rectumUlcers in the lining of the colon and rectumBleeding in the lining of the colon and rectum
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The exact cause is unknown. A virus or bacteria may cause the immune system to overreact and damage the colon and rectum.
Having a family member with IBD (includes UC and
Crohn's disease) may increase your risk of developing UC.
UC may cause: DiarrheaAbdominal cramps and painRectal bleedingAnemiaWeight lossFatigue, weaknessNauseaFeverSkin rashesArthritis
Eye inflammation, such as
Intestinal complications of UC may include: PerforationFistula—abnormal passageway between 2 bodily structuresObstructionExcess bleedingToxic megacolon—a potentially life-threatening condition when the colon severely expands, which may result in reduced blood flow
Other complications of UC may include: Liver diseaseKidney stonesOsteoporosisColon cancer
Treatment options may include:
Your doctor may recommend that you avoid certain foods, such as:
Dairy (due to
AlcoholRed and processed meatsRefined sugarSaturated fat
Talk to your doctor or dietitian about what foods may work best for you.
There are a range of medications that may be prescribed, such as: AminosalicylatesSteroid anti-inflammatory medicationsImmune modifiersBiological agents
partial or complete removal of the colon. This may be necessary for:
An emergency, such as a perforation, excessive bleeding, or life-threatening infectionLong-term disease that does not respond to medications or other treatmentColon cancer—includes confirmed diagnosis or suspicious tissue on examination
Lack of growth because of nutritional deficiencies (in children)
Surgery for UC is curative and reduces the risk of colon cancer.
Fecal transplantation may be used to treat UC.
There are no current guidelines for preventing UC.
D'Haens GR, Sartor RB, Silverberg MS, Petersson J, Rutgeerts P. Future directions in inflammatory bowel disease management. 2014;8(8):726-734.
Richman S, Schub T. Ulcerative colitis. EBSCO Nursing Reference Center website. Available at: http://www.ebscohost.com/nursing/products/nursing-reference-center. Updated August 2012. Accessed September 30, 2014.
Wedlake L, Slack N, Andreyev HJ, Whelan K. Fiber in the treatment and maintenance of inflammatory bowel disease: a systematic review of randomized controlled trials. Inflamm Bowel Dis. 2014;20(3):576-586.
What is ulcerative colitis? Crohn's & Colitis Foundation of America website. Available at:
www.ccfa.org/what-are-crohns-and-colitis/what-is-ulcerative-colitis. Accessed September 30, 2014.
8/31/2015 DynaMed Plus Systematic Literature Surveillance Update http://www.dynamed.com/topics/dmp~AN~T114507/Ulcerative-colitis: Moayyedi P, Surette MG, Kim PT, et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology. 2015;149(1):102-109.
Last reviewed August 2015 by Daus Mahnke, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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