Retinopathy of prematurity (ROP) is a rare eye condition. It occurs in infants who are premature or have low birthweight. ROP causes a problem in the retina, the tissue that lines the back of the eye.
The blood vessels in the retina grow abnormally.
The abnormal blood vessels can lead to bleeding and scarring in the retina. In the most serious cases, ROP can lead to a separation of the retina from the back of the eye. In a small number of cases, ROP may cause vision loss or blindness.
Normal Anatomy of the Eye
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The exact cause of ROP is unknown.
Factors that increase the chance of an infant developing ROP include: Premature birth
, especially babies born less than 30 weeks gestation
Low birth weight, especially babies weighing less than three poundsLow or fluctuating oxygen levelsRespiratory distressAnemia
There are usually no signs of ROP until it reaches a severe stage. Severe ROP may cause: White pupilsAbnormal eye movementsCrossed eyes (turning toward each other)Amblyopia
A specialist will screen for ROP if your infant has risk factors such as prematurity and low birth weight. The doctor will use a special eye exam to view the blood vessels in the retina.
The doctor will examine your infant’s eyes every 1-2 weeks until the blood vessels in the retina are fully developed.
ROP will usually heal on its own. Your baby's eye will be examined regularly until the blood vessels heal.
More severe ROP may require treatment to reduce the risk of the retina detaching from the back of the eye. Treatment options include: Cryosurgery—freezing tissue in the eye to prevent the spread of abnormal blood vesselsLaser ablation/photocoagulation—a laser stops abnormal blood vessels from growing
The best way to prevent ROP is to prevent premature birth. Good prenatal care will help decrease the risk of premature birth.
Fierson WM, American Academy of Pediatrics Section on Ophthalmology, American Academy of Ophthalmology; American Association for Pediatric Ophthalmology and Strabismus, American Association of Certified Orthoptists. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2013;131(1):189-195.
Retinopathy of prematurity. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated June 10, 2013. Accessed June 24, 2013.
Retinopathy of prematurity. National Eye Institute website, Available at:
http://www.nei.nih.gov/health/rop. Accessed June 24, 2013.
Last reviewed January 2015 by Kari Kassir, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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