The information provided here is meant to give you a general idea about each of the medications listed below. Only the most general side effects are included, so ask your doctor if you need to take any special precautions. Use each of these medications as recommended by your doctor, or according to the instructions provided. If you have further questions about usage or side effects, contact your doctor.
Hormones are chemical messengers that regulate specific body functions. They are produced by various glands in the body and enter the blood stream, where they travel to other tissues and exert their influence. Hormonal therapy is used in cancer treatment to augment or interfere with the activity of certain hormones that can influence the growth of tumors.
Hormonal therapy is an important adjunct for thyroid cancer. It is delivered in the form of thyroid hormone pills. Hormonal therapy is used both to treat the deficiency of thyroid hormone that occurs after the thyroid gland is removed or destroyed and to prevent or delay remaining bits of thyroid tissue from growing by suppressing thyroid-stimulating hormone (TSH) secreted from the pituitary gland.
There are several types of thyroid hormones which could be used:
LevothyroxineLiothyronine—used postoperatively to prepare for radioiodine scanThyrotropin alfa—a synthetic TSH used to prepare for scanning or for thyroglobulin blood level measurement
Giving thyroid hormone seems to decrease the chance that remaining bits of thyroid tissue will grow. No one is sure how long patients should continue to be treated with thyroid hormone, however.
Since the elderly may have an underlying heart, liver, or kidney disease, these hormone medications should be used with caution in this population. You may notice a skin rash within the first few months of treatment with thyroid hormone.You may lose more hair than usual within the first few months of treatment with thyroid hormone.
Levothyroxine or liothyronine may causes symptoms similar to overactive thyroid including rapid heart rate,
insomnia, weight loss, sweating, flushing in the face, or
Thyrotropin alfa often causes nausea, muscle weakness, or headache.
You’ll need to be monitored regularly and carefully to make sure that you are receiving an appropriate dose of thyroid hormone. Too little hormone will cause
hypothyroidism, which has the following symptoms:
Weight gainCold intolerance (you constantly feel chilly when others are comfortable)Dry skinDry hairLow energyMuscle or joint pains
Too much hormone can cause
hyperthyroidism, which has the following symptoms:
Weight lossFeeling overheated, sweatyDiarrheaAbdominal crampsChest painNervousnessFeeling jittery or “hyper”
Baudin E, Schlumberger M. New therapeutic approaches for metastatic thyroid carcinoma.
Conn’s Current Therapy.
54th ed. Philadelphia,PA: WB Saunders Company; 2002: 652-657.
Cooper DS, Doherty GM, et al: The American Thyroid Association Guidelines Taskforce: management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
Cornett WR, Sharma AK, et al. Anaplastic thyroid carcinoma: an overview.
Curr Oncol Rep.
Rachmiel M, Charron M, et al. Evidence-based review of treatment and follow up of pediatric patients with differentiated thyroid carcinoma.
J Pediatr Endocrinol Metab.
Thyroid carcinoma. In:
Cecil Textbook of Medicine.
21st ed. Philadelphia, PA: WB Saunders Company; 2000: 1247-1250.
What is thyroid cancer. American Cancer Society website. Available at
http://www.cancer.org/docroot/CRI/CRI_2_3x.asp?dt=43. Accessed December 10, 2002.
What you need to know about cancer of the thyroid. National Cancer Institute website. Available at
http://cancer.gov. Accessed December 10, 2002.
Last reviewed September 2014 by Mohei Abouzied, MD, FACP
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved.