Oxygen is needed in every cell of the body. It first enters the body through the lungs. The oxygen is then picked up by the blood flowing by the lungs. The blood brings oxygen to the rest of the body. In newborns with persistent pulmonary hypertension (PPHN), the blood does not flow by the lungs.
The baby's lungs are not used during pregnancy. Instead, oxygen passes from the mother to the baby through the umbilical cord, bypassing the lungs. After the baby is born, the baby's lungs should take over. When this does not occur, most of the blood flow bypasses the lungs, does not pick up oxygen, and the body does not get enough oxygen.
PPHN can be a serious condition. It can cause both immediate and long-term health problems.
Circulatory System of Infant
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PPHN can be caused by a variety of factors, including:
An event or illness during pregnancy or childbirth, such as:
Meconium aspiration syndrome (the baby inhales meconium—the first stool—prior to or shortly after birth)
pneumoniaInfectionLow blood sugarBirth asphyxia (loss of oxygen to the fetus during delivery)Respiratory distress syndrome—caused by lungs that have not fully developed
Use of nonsteroidal anti-inflammatory drugs (NSAIDs) by the mother during pregnancyLate trimester maternal use of antidepressants, especially SSRIsAmniotic fluid leak
Low amniotic fluid—oligohydramniosAbnormal lung development as a result of congenital diaphragmatic hernia or Potter syndromeStress during pregnancyIsolated condition with an unknown cause
Factors that may increase your baby’s chance of PPHN include: Stress to the fetus during pregnancy or delivery
Health conditions of the mother, including
diabetesComplications during birth or pregnancy
PPHN may cause Rapid breathing—tachypnea
Rapid heart rate—tachycardiaDifficulty breathing—signs may include flared nostrils or gruntingBlue tint to the skin, even when the baby is receiving oxygen
You will be asked about your baby’s symptoms. Your pregnancy history may also be reviewed. A physical exam will be done.
Your baby's bodily fluids may be tested. This can be done with: Blood testsPulse oximetry monitoring—continuous monitoring of oxygen levels in the blood
Images may be taken of your baby's bodily structures. This can be done with: Chest x-rays—to help diagnose lung disease or enlarged heart
Echocardiogram—ultrasound of the heart to show the baby's circulating blood flow
Head ultrasound—to look for bleeding in the brain
Treatment for PPHN is typically given by a doctor who specializes in newborn illness.
Treatment begins with correcting any related conditions. These conditions can include low blood sugar, low oxygen levels, low blood pressure, and low blood pH. Treatment may include:
Extra oxygen is the most important treatment for PPHN. Oxygen will relax blood vessels to the lungs and improve the flow of blood to the lungs. It may be given with nasal prongs or a hood.
A ventilator is a machine that will help your baby breathe. It may be used if your baby can not get enough oxygen in other ways. A tube will be placed in the baby's throat. The tube is connected to the ventilation machine. The ventilator will deliver air and oxygen with gentle pressure. The pressure will help keep the lungs open.
Nitric oxide is a gas. It may be delivered before or during ventilation. Nitric oxide may relax blood vessels. This will also improve the flow of blood in the lungs.
Medications may be given to relax your infant, especially if a ventilator is needed.
There are a number of new medications to treat PPHN that are being reviewed. One example is
sildenafil, which is used to treat
erectile dysfunction. Small studies have shown positive results with sildenafil. However, larger studies are needed to confirm the benefits and safety of the medication.
ECMO is a machine that can take over the job of the lungs. It requires major surgery. ECMO may be done if your child has a severe cases of PPHN that is not responding to other treatments. This procedure is done to take some stress off of your baby's body. It can give your baby some time to heal.
Most cases of PPHN have no clear cause or are caused by uncontrollable events. For these cases there are no clear preventative steps. Some cases of PPHN may be prevented with proper prenatal care and good health of the mother during pregnancy. General tips for a healthy pregnancy include: Get good prenatal care. Start as early as possible in pregnancy.Eat a healthful diet and take recommended vitamins.Avoid smoking, drinking alcohol, and taking drugs.Only take medications that your doctor has approved.Avoid taking certain anti-inflammatory or antidepressant medication. Talk to your doctor about alternatives that may be safer.
Extracorporeal membrane oxygenation. Cincinnati Children's Hospital website. Available at:
http://www.cincinnatichildrens.org/health/e/ecmo. Updated May 2015. Accessed September 14, 2015.
Lungs and respiratory system. Children's Hospital Colorado website. Available at:
Updated October 2012. Accessed September 14, 2015.
Persistent pulmonary hypertension of the newborn (PPHN). EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated June 12, 2015. Accessed September 14, 2015.
PS Shah, A Ohlsson. Sildenafil for pulmonary hypertension in neonates. Cochrane Database Syst Rev 2007; 3:CD005494.
Last reviewed September 2015 by Kari Kassir, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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