In Japan, various mushrooms and tree fungi have a long history of medicinal use. Active Hexose Correlated Compound (AHCC) is a proprietary compound made from the mycelia (vegetative portion) of various mushrooms in the general family of basidiomycete. The exact composition of the mushrooms, as well as the method used to prepare them, are considered a trade secret. AHCC has been developed in Japan for use in treatment of cancer. For related treatments, see the articles on
A typical dose of AHCC is 3 grams daily, often divided into 3 doses.
While use of AHCC has not been associated with any severe adverse effects, this substance has not undergone thorough safety testing. Safety in young children, pregnant or nursing women, or people with severe liver or kidney disease has not been established.
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Ritz BW, Nogusa S, Ackerman EA, et al. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection.
Aviles H, Belay T, Vance M, et al. Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions.
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Ikeda T, Ishibashi H, Fujisaki R et al. Prophylactic efficacy of a basidiomycetes preparation AHCC against lethal
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Aviles H, Belay T, Fountain K, et al. Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infection in mice in the hindlimb-unloading model of spaceflight conditions.
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Burikhanov RB, Wakame K, Igarashi Y, et al. Suppressive effect of active hexose correlated compound (AHCC) on thymic apoptosis induced by dexamethasone in the rat.
Last reviewed December 2015 by EBSCO CAM Review Board
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