There are no lab tests to definitively diagnose
. Your doctor will ask about your medical history and do a thorough physical exam.
There are 4 hallmark symptoms of Parkinson’s disease, but these may not all be present. If that is the case, your doctor may examine you every few months to check on your symptoms.
hese symptoms include: Tremor while at restRigiditySlowness of movement (bradykinesia)Postural instability
A neurological exam will include a range of tests to evaluate your strength, coordination, balance, and other aspects, such as: Muscle toneRapid alternating movementsGait, posturePostural stabilityQuickness and precision of movementObservation of a tremor (during rest or activity)
A mini-mental status test may be done. Activities of daily living may also be evaluated, such as dressing, cutting and eating food, swallowing, hygiene, walking, and falls.
If the diagnosis is not clear, you may be given tests to try to eliminate the possibility of other conditions with similar symptoms. These tests may include: Blood testsUrine testsMRI scanCT scan
Your doctor may also give you a trial of levodopa, a medication that increases the amount of dopamine your brain produces. A positive response to this medication may help to confirm the diagnosis.
Your doctor may also have imaging tests done, such as: SPECT scan—Contrast material is used to make it easier to see structures in the brain. A dopamine transporter scan (DATscan) may be used to evaluate your condition.
NINDS Parkinson's disease information page. National Institute of Neurological Disorders and Stroke
website. Available at:
http://www.ninds.nih.gov/disorders/parkinsons_disease/parkinsons_disease.htm. Updated June 2, 2016. Accessed June 16, 2016.
Obeso JA, Rodriguez-Oroz MC, Goetz CG, et al. Missing pieces in the Parkinson’s disease puzzle.
Nature Medicine. 2010;16(6):653-661.
Parkinson disease. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/neurologic-disorders/movement-and-cerebellar-disorders/parkinson-disease. Updated September 2015. Accessed June 16, 2016.
Parkinson's disease. American Association of Neurological Surgeons
website. Available at:
http://www.aans.org/en/Patient%20Information/Conditions%20and%20Treatments/Parkinsons%20Disease.aspx. Accessed June 16, 2016.
Ravina B, Marek K, Eberly S, et al. Dopamine transporter imaging is associated with long-term outcomes in Parkinson's disease.. Mov Disord. 2012;27(11):1392-1397.
Varrone A, Haldin C. New developments of dopaminergic imaging of Parkinsons disease. Q J Nucl Med Mol Imaging. 2012:56(1):68-82.
9/3/2014 DynaMed Plus Systematic Literature Surveillance. Available at:
http://www.dynamed.com/topics/dmp~AN~T115172/Parkinson-disease: Wippold FJ, Cornelius RS, Broderick DF, et al. American College of Radiology (ACR) Appropriateness Criteria for dementia and movement disorders. Available at: https://acsearch.acr.org/docs/69360/Narrative. Updated 2014. Accessed September 3, 2014.
Last reviewed June 2016 by Rimas Lukas, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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