uses drugs to kill cancer cells. The drugs enter the bloodstream and travel through the body in order to kill cancer cells. The side effects from the chemotherapy come from the fact that it destroys normal cells as well. Chemotherapy may be given either alone or along with
. When given alone, it is given in a higher dose designed to kill off cancer cells. When given along with radiation therapy, it is delivered at a lower dose and is designed to make the cancer more sensitive to the radiation.
The amount and type of chemotherapy you receive will be determined by the stage and type of Hodgkins disease, as well as factors such as your age and health. Main drug regimen: ABVD (doxorubicin
Other drug regimens: MOPP (
alternating with ABVD
ABV, COPP, and ChlVPP (chlorambucil
[Leukeran], vincristine, prednisone, and procarbazine)
Other regimens are in development, and you may be eligible for a treatment trial depending on your stage and health. In addition, chemotherapy may be used to prepare a patient for
bone marrow transplantation
, which may also be used in advanced cases of Hodgkins disease or in cases of relapse.
The side effects and amount of time required in the doctor’s office depend on the type of chemotherapy you receive, as well as how many cycles you receive and how often.
Possible side effects of chemotherapy include: Bone marrow suppression
resulting in infectionLow white blood cell countsLow red blood cell countsLow platelet countsHair lossAppetite lossTaste changesNausea and vomitingInflammation and sores in the mouth, throat, and esophagusConstipationDiarrheaFatigueReproductive and sexuality problems and hormonal changes, such as hypogonadism
In addition, certain chemotherapy drugs can cause: Heart damageNervous system changesLung damageLiver damageKidney and urinary system damage
The likelihood and extent of these side effects will vary according to each patient. Ask your doctor what you are likely to experience. If you develop any new symptoms, be certain to report them to your doctor right away. These complications of treatment are always more easily managed when discovered early.
When chemotherapy is given at a lower dose, as when it is given along with radiation, these side effects are less common. However, most people still feel very fatigued.
Some of the medications associated with these procedures may cause infertility. If your fertility is a concern, discuss the possibility of storing sperm or eggs before starting treatment.
Last reviewed October 2012 by Mohei Abouzied, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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