Acanthosis nigricans is a skin condition in which brown or black velvet-like markings appear under the arms, in the groin, or on the back of the neck. Any skin fold can be affected, including the lower lip and chin.
Causes of acanthosis nigricans may include: High insulin levels in people who are obeseA family history of acanthosis nigricansA cancerous tumor—rare
Acanthosis nigricans is more common in people of African-American decent. Other factors that increase your chances of getting acanthosis nigricans include:
overweightType 2 diabetesPolycystic ovary syndrome
velvety-looking, dark areas anywhere on the skin.
You will be asked about your symptoms and medical history. A physical exam will be done.
Your bodily fluids may be tested. This can be done with:
Your bodily structures may need to be viewed. This can be done with: X-raysEndoscopy
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Treatment often involves treating the underlying cause. For example, if acanthosis nigricans is due to obesity, weight loss can improve the skin condition.
Topical and oral retinoids and other medications have been reported to improve appearance in some cases. They help remove excess layers of skin.
To reduce your chances of getting acanthosis nigricans, take these steps: Maintain a healthy weightEat a balanced dietGet regular exercise most days of the weekTalk to your doctor about your blood sugar levels
Acanthosis nigricans. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated December 10, 2010. Accessed August 8, 2014.
Clark N, Stulberg DL, et al. Common hyperpigmentation disorders in adults: part II. Melanoma, seborrheic keratoses, acanthosis nigricans, melasma, diabetic dermopathy, tinea versicolor, and postinflammatory hyperpigmentation.
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Goff DC, et al. Acanthosis nigricans
in obese patients: presentations and implications for prevention of atherosclerotis vascular disease.
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DynaMed's Systematic Literature Surveillance
http://www.ebscohost.com/dynamed: Kong AS, Williams RL, et al. Acanthosis nigricans and diabetes risk factors: prevalence in young persons seen in southwestern US primary care practices.
Ann Fam Med.
Kong AS, Williams RL, et al. Acanthosis Nigricans: high prevalence and association with diabetes in a practice-based research network consortium—a PRImary care Multi-Ethnic network (PRIME Net) study.
J Am Board Fam Med.
Last reviewed August 2014 by Brian Randall, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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