Definition

Acute interstitial nephritis is a kidney disorder that happens when the kidneys are unable to filter waste and fluid properly due to inflammation of the kidney.

The Kidneys

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Causes

Acute interstitial nephritis can be caused by:

    
  • Certain medications     
  • Antibiotics
  • Anti-ulcer drugs
  • Nonsteroidal anti-inflammatory drugs
  • Diuretics
  • Infections such as:     
  • Streptococcus
  • Herpes
  • Mumps
  • Hepatitis C
  • Syphilis
  • HIV
  • Conditions that affect the immune system such as lupus
  • Risk Factors

    Risk factors that increase your chance of developing acute interstitial nephritis include:

        
  • In adults: drug or medication use
  • In children: infection
  • Symptoms

    Symptoms include:

        
  • Decrease in urine output
  • Blood in urine
  • Side or loin pain
  • Swelling of the body
  • Nausea and vomiting
  • Loss of appetite
  • Weakness
  • Aching joints
  • Fever
  • Rash
  • Diagnosis

    Your doctor will ask about your symptoms and medical history. A physical exam will be done. Tests may include:

        
  • Blood Tests
  • Urine tests
  • Kidney biopsy
  • Kidney ultrasound
  • Treatment

    Talk with your doctor about the best treatment plan for you. You treatment will depend on the cause of your acute interstitial nephritis. Treatment options include the following:

    Medications

    If medications are the cause of your interstitial nephritis, your doctor may have you stop taking medications or prescribe a different one.

    Your doctor may prescribe the following:

        
  • Antibiotics to treat infection
  • Corticosteroid or cyclophosphamide to treat interstitial nephritis
  • Usually, a kidney biopsy is done to confirm the diagnosis before starting a corticosteroid or cyclophosphamide.

    Dialysis

    Some people with interstitial nephritis need dialysis . During dialysis, a machine does the work of your kidneys by removing waste.

    Prevention

    To help reduce your chances of developing acute interstitial nephritis, your doctor may suggest you avoid certain medications such as penicillin or nonsteroidal anti-inflammatory drugs.