has a long history of use in the traditional
system of India. Its bark has been used for treating diabetes, diarrhea, fever, arthritis, gonorrhea and skin diseases.
Since the late 1990's,
has undergone modern research that has, to a certain highly preliminary extent, substantiated its traditional reputation as a treatment for
may work similarly to the standard diabetes drug Acarbose, used in type 2 diabetes. Acarbose inhibits the intestinal enzyme alpha-glucosidase, an enzyme responsible for helping to digest carbohydrates. When alpha-glucosidase is inhibited, carbohydrate absorption is slowed, thereby reducing the rise in blood sugar that follows a meal.
double-blind, placebo controlled study
published in 2005 evaluated the effects of
extract taken at a dose of 1000 mg daily.
In this study, 43 healthy people were given a high carbohydrate beverage with or without addition of the herb. The results showed that when the herbal extract was included, the normal rise in blood sugar and insulin following consumption of the beverage was significantly decreased. Additional evidence collected in this study (breath hydrogen levels) supported that hypothesis that S. oblonga works by inhibiting alpha-glucosidase.
Another double-blind study compared the effectiveness of various doses of
extract: 0, 500, 700 or 1000 mg daily.
Again, participants were given a high carbohydrate beverage. The results in these 39 people showed that the highest dose but not the lower doses significantly improved post-meal blood sugar and insulin levels. This type of "dose-related" effect, where higher doses have a greater effect, tends to bolster the confidence researchers can place in the results of a study.
However, neither of these studies involved people with diabetes. Further research will be necessary to actually determine whether
is a useful treatment for people with this this condition.
Besides effects on carbohydrate absorption, some evidence weakly hints that
might inhibit the enzyme aldose reductase.
In theory, this effect could mean that use of the herb might help prevent certain
complications of diabetes
, such as cataracts, peripheral neuropathy and retinopathy.
However, as yet the evidence to support this possibility remains far too preliminary to rely upon at all.
has been marketed for
type 2 diabetes, as well as for aiding in
. However, there is as yet no evidence whatsoever that it offers either of these benefits.
A typical dose of
is 2.5 to 5.0 grams daily of the whole herb, or a comparable amount as extract. The root bark is the part of the plant used.
is believed to be relatively safe. Some evidence suggests that Salacia oblonga does not damage DNA.
Studies in rats have shown a good safety profile.
In human studies, the primary side effects seen are identical to the side effects of standard alpha-glucosidase inhibitors: gas and cramping.
Maximum safe dosages are not known for pregnant or nursing women, or people with severe liver or kidney disease.
Collene AL, Hertzler SR, Williams JA et al. Effects of a nutritional supplement containing Salacia oblonga extract and insulinogenic amino acids on postprandial glycemia, insulinemia, and breath hydrogen responses in healthy adults.
Heacock PM, Hertzler SR, Williams JA et al. Effects of a medical food containing an herbal alpha-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults.
J Am Diet Assoc
Matsuda H, Murakami T, Yashiro K et al. Antidiabetic principles of natural medicines. IV. Aldose reductase and qlpha-glucosidase inhibitors from the roots of Salacia oblonga Wall. (Celastraceae): structure of a new friedelane-type triterpene, kotalagenin 16-acetate.
Chem Pharm Bull (Tokyo)
Flammang AM, Erexson GL, Mecchi MS et al. Genotoxicity testing of a Salacia oblonga extract.
Food Chem Toxicol
. 2006 Jun 28 [Epub ahead of print]
Wolf BW, Weisbrode SE. Safety evaluation of an extract from Salacia oblonga.
Food Chem Toxicol
Li Y, Huang TH, Yamahara J. Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity.
2008 Mar 28.
Last reviewed September 2014 by EBSCO CAM Review Board
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved.