Neonatal sepsis is a bacterial infection in the blood. It is found in infants during the first month of life. This may become a serious condition. If you suspect your infant has this condition, contact your doctor right away.
Spread of Infection
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Early-onset sepsis develops in the first 2-3 days after birth. Late-onset sepsis develops within 3-7 days after birth.
Neonatal sepsis is caused by bacteria. The infant may come in contact with bacteria during pregnancy, birth, or from the environment after birth.
Early-onset sepsis is caused by an infection from the mother. It may pass to the infant from the placenta or birth canal during birth. Antibiotics may be given to high risk mothers during labor. This may prevent early-onset bacterial sepsis in some infants.
Late-onset sepsis is caused by bacteria from the healthcare environment.
Infant boys have a higher risk for neonatal sepsis. Other factors that may increase your infant’s chance of neonatal sepsis include: Premature birth—more than 3 weeks before due dateEarly labor—more than 3 weeks before your due dateFetal distress before birthInfant has a very low birth weightFetus has a bowel movement before birth and fetal stool is in the uterusAmniotic fluid surrounding the infant has a bad smell or the infant has a bad smell right after being born
Pregnancy conditions or mother's health issues that increase your infant's chance of neonatal sepsis include:
Labor complications resulting in traumatic or
Water that broke more than 18 hours before giving birthFever or other infections during laborNeed for a catheter for a long time while you are pregnantPresence of group B streptococcal bacteria in vaginal or rectal areasMany courses of prenatal steroidsProlonged internal monitoring during labor and delivery
In most cases of early-onset sepsis, symptoms are present within 24 hours of birth. In almost all cases, symptoms will be present within 48 hours of birth. If your infant has any one of these symptoms, especially in first week, contact your doctor. Fever or frequent changes in temperatureBreathing rapidly, difficulty breathing, or periods of no breathing (apnea)Lethargy (abnormal sleepiness)
Poor feeding from
Decreased or absent urinationBloated abdomenVomiting yellowish materialDiarrheaExtreme redness around the belly buttonSkin rashesDifficulty waking your infant or unusual sleepinessJaundiced
or overly pale skin
Abnormally slow or fast heartbeatBruising or bleedingSeizuresCool, clammy skin
It is important for your doctor to evaluate any fever in your infant.
Your doctor will ask about your infant’s symptoms and medical history. A physical exam will be done.
Tests may include the following: Blood testsBlood and urine culturesLumbar puncture
—to evaluate cerebrospinal fluid that protects the brain and spinal cord
Samples of skin lesions
Chest and/or abdominal
Talk with your doctor about the best treatment plan for your infant. Treatment depends on how severe the condition is. If sepsis is suspected, your infant will be hospitalized while you wait for test results.
Treatment may last 2-21 days.
A well-appearing infant may be monitored without antibiotics. Your infant will be
when tests show there are no bacteria. Sepsis that is confirmed with a culture test is treated for 7-21 days. Treatment will depend on the location of the infection and may include:
Antibiotics may have to be given through an IV.
IV fluids will help support your infant until the infection clears. It may include fluids, glucose, and electrolytes.
Your infant may need
therapy. In more severe cases, a ventilator may be used to support breathing.
To reduce your infant’s chance of getting neonatal sepsis, your doctor may take the following steps:
Antibiotics can control dangerous bacteria in the mother. It will prevent the spread of bacteria during pregnancy or birth to the infant. Your doctor may recommend antibiotics if:
The birth mother has previously given birth to an infant with neonatal sepsis.You have had a positive bacterial infection test before your due date.Breastfeeding may also help prevent sepsis in some infants.Follow steps to prevent premature labor or birth. This can include proper prenatal care, avoiding drugs and alcohol, and eating a healthy balanced diet.
Early-onset neonatal sepsis. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated September 3, 2013. Accessed August 21, 2014.
Kleigman RM, Behrman RE, Jenson HB, Stanton BF.
Nelson Textbook of Pediatrics. 18th ed. Philadelphia, PA: Saunders; 2004.
Late-onset neonatal sepsis. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated March 17, 2014. Accessed August 21, 2014.
Neonatal sepsis (sepsis neonatorum). The Merck Manual Professional Edition website.
http://www.merckmanuals.com/professional/pediatrics/infections_in_neonates/neonatal_sepsis.html. Updated May 2013. Accessed August 21, 2014.
Last reviewed August 2014 by Kari Kassir, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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